Which medication is known for increasing the risk of seizures in patients with eating disorders?

Bupropion is well-known for increasing the risk of seizures, particularly in patients with eating disorders such as anorexia or bulimia. This is primarily due to its effect on the brain's neurotransmitters and its potential to lower the seizure threshold, especially when patients are engaged in activities that may already compromise their physical health, such as severe caloric restriction or electrolyte imbalances associated with eating disorders.

In clinical practice, healthcare providers exercise caution when prescribing bupropion to populations at risk, which includes individuals with a history of eating disorders. The other medications listed—fluoxetine, citalopram, and duloxetine—are generally regarded as safer options in this context, as they do not have the same potential for increasing seizure risk, making them more suitable for patients with eating disorders.