What is one of the mechanisms of action of GLP-1 agonists?

One of the mechanisms of action of GLP-1 agonists is the increase in insulin release in response to rising glucose levels. GLP-1 (glucagon-like peptide-1) is an incretin hormone that is released from the gut after eating, and it plays a critical role in glucose metabolism. By stimulating the pancreatic beta cells, GLP-1 agonists enhance insulin secretion when blood glucose levels are elevated. This response helps to lower blood sugar levels effectively, making GLP-1 agonists valuable in managing type 2 diabetes.

Additionally, GLP-1 agonists also promote satiety, slow gastric emptying, and inhibit glucagon secretion, but the primary focus of the question is on their role in insulin release. This mechanism is particularly advantageous because it is glucose-dependent; the agonists enhance insulin secretion only when glucose levels are high, reducing the risk of hypoglycemia, which is a common concern with other diabetes medications.